Search results for " oropharyngeal cancer"
showing 2 items of 2 documents
The role of the innate immune response in HPV-related oral and oropharyngeal cancer
2014
Introduction. During the last 20 years, the incidence of HPV-associated oropharyngeal cancer is increased. Principal actors of the innate immune response against HPV are represented by the TLRs (Toll like receptors). On the other hand different studies have reported that HPV can directly inhibit the functions of the TLRs pathway through interferons (IFNs). There are very few preliminary studies on the role of TLRs mediated HPV clearance in human oncology. Our study aim has been to evaluate whether TLR4 identifies HR-HPV integration state in OSCC. Methods. Protein levels of TLR4 in OSCC were assessed using Immunohistochemistry (IHC). In situ hybridization (ISH) for HPV-DNA detection in morph…
Human Papillomavirus Infection: A Risk Factor for Oral and Oropharyngeal Cancers
2020
A wide range of human papillomavirus (HPV) prevalence data is now available for head and neck squamous cell carcinomas (HNSCCs), especially for those cancers originating from the epithelial lining of the upper aero-digestive tract (UADT) (i.e., the pharynx, the larynx, and the oral cavity). There is strong evidence that supports HPV as an etiological cause of head and neck carcinogenesis particularly for distinct oropharyngeal subsites. A specific molecular, histopathological, clinical, and prognostic profile is intimately connected with HPV infection. While the role of HPV in oropharyngeal carcinogenesis is firmly acknowledged, its role in oral cancer is currently being debated. Several re…